Research

NOTE: For a list of currently active trials, please visit our Clinical Trials page.

Completed Trials as collaborator/ site investigator for multi-center trials (with publication, if available):

PRAISE 2 - Site Investigator - 1998  - Trial evaluating effect of amlodipine (Norvasc) in CHF patients with non-ischemic cardiomyopathy - trial completed

Niaspan Combination - Phase 4 - Site Investigator - 1998 -Open label study of
intermediate release niacin (Niaspan) in patients on statin therapy - trial completed

Growth Hormone Releasing Hormone Trial in CHF - Site Investigator -1999 Pfizer Phase 3 Clinical trial of Oral GHRH agent in CHF and LV systolic dysfunction

PRINCE - Site Investigator - 2000 - Trial evaluating effect of pravastatin (Pravachol) on hs-CRP levels - trial completed Published: Albert MA, Danielson E, Rifai N, Ridker PM; PRINCE Investigators JAMA. 2001 Jul 4;286(1):91-3

MERIT - Site Investigator - 1998 -Randomized Intervention Trial in congestive heart failure evaluating effect of metoprolol (Toprol) on outcomes for patients NYHA Class 2 - 3  Results Published Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, Wikstrand J, El Allaf D, Vitovec J, Aldershvile J, Halinen M, Dietz R, Neuhaus KL, Janosi A, Thorgeirsson G, Dunselman PH, Gullestad L, Kuch J, Herlitz J, Rickenbacher P, Ball S, Gottlieb S, Deedwania P  JAMA 2000 Mar 8;283(10):1295-1302

BARI - Site Co-Investigator - 1991 - Investigation of bypass vs angioplasty in patients with coronary artery disease - trial completed. Published N Engl J Med 1996 Jul 25;335(4):217-225.

MARCATOR - Site Co-Investigator -1991 - Investigation of cilazapril in restenosis after balloon angioplasty - trial completed Published:  Faxon DP. J Am Coll Cardiol 1995 Feb;25(2):362-

Valsartan Exercise - Site Investigator - 1999 - Investigation of addition of ARB therapy valsartan (Diovan) in exercise outcome with CHF patients already on therapy with ACEI - trial complete

OVERTURE - Site Investigator - 2000 -Comparison of Omapatrilat and Enalapril in Patients With Chronic Heart Failure The Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE) Milton Packer, MD; Robert M. Califf, MD; Marvin A. Konstam, MD; Henry Krum, MBBS, PhD; John J. McMurray, MD; Jean-Lucien Rouleau, MD; Karl Swedberg, MD; for the OVERTURE Study Group* Circulation. 2002;106:r21-r27

VITAL - Site investigator - 2001 Investigation of Vasopressin Inhibition with Tolvaptan in CHF patients - trial complete

WIZARD - Site investigator - 1999 - Azithromycin for the Secondary Prevention of Coronary Heart Disease Events: The Wizard Study: A Randomized Controlled Trial  C. M. O'Connor et al  JAMA 2003; 290:1459-1466.

SIRIUS - Site Co-investigator - 2001 Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery Jeffrey W. Moses, M.D., Martin B. Leon, M.D., Jeffrey J. Popma, M.D., Peter J. Fitzgerald, M.D., Ph.D.,David R. Holmes, M.D., Charles O'Shaughnessy, M.D., Ronald P. Caputo, M.D., Dean J. Kereiakes, M.D., David O. Williams, M.D., Paul S. Teirstein, M.D., Judith L. Jaeger, B.A., and Richard E. Kuntz, M.D., for the SIRIUS Investigators N Engl J Med 2003;349:1315-23.

SPORTIF V - Site Investigator - 2001 - Investigation of Oral direct thrombin inhibitor Astra Zeneca H376/95 on thromboembolic stroke in atrial fibrillation patients - trial completed 12-2002, to be presented AHA November 2003

CAPTIVE - evaluation of MedNova emboshield distal protection device compared to Medtronic Percusurge in saphenous vein graft intervention (PCI)  - trial completed 5-2003

PROVE IT - Site Investigator - 2001 Investigation 2 x2  of Lipitor 80 vs. Pravachol 40 and Gatifloxacin vs. placebo in patients with acute coronary syndromes - trial completed October 2003

EASE - randomized trial of add on therapy with ezetimibe to statin therapy in patients who have achieved inadequate lipid lowering, completed August 2003

METEOR -Multicenter Evaluation of Tolvaptan Effects on Left Ventricular Remodeling - Effects of Oral Tolvaptan on Left ventricular dilation and function in patients with heart failure and left ventricular systolic dysfunction - trial completed

TAXUS V - TAXUS Express Paclitaxel eluting stent in high-risk de novo coronary lesions- trial completed

TAXUS VI Evaluation of Slow release Formulation TAXUS Paclitaxel Eluting Stent in the treatment of In-Stent Restenosis - trial completed

Prevention of Sporadic Colorectal Adenomas with a Cox-2 inhibitor. Scott D. Solomon, MD, John McMurray, MD, Marc A. Pfeffer, MD, et al.  Cardiovascular Risk Associated with Celecoxib in a Clinical Trial for Colorectal Adenoma Prevention. NEJM 2004; 352.